This is from a journal article in the Plastic and Reconstructive Surgery Journal October 2022. “The Role of NAD+ in Regenerative Medicine.”
I became interested in regenerative medicine as I aged and as I saw the benefits in my patients from doing fat grafting which has stem cells in it. The stem cell improvement in skin is visible. Plastic surgeons are interested in regenerative medicine from a beauty perspective, but it also helps with anti aging, skin health (skin laxity, thickness, wrinkling, healing), and healing from surgery.
This article was a synopsis of many mice studies.
- NAD+ levels decrease twofold by middle age.
- The loss in NAD+ correlates with age related issues.
- When you do things to raise levels of NAD+ to “youthful levels” you see
- heart and blood pressure improvement,
- reversal of metabolic conditions,
- muscle endurance and function improves, with more and better quality muscle stem cells,
- better mitochondrial function,
- better protection and regeneration after injury for the kidney, liver, and heart
- Reversal of retinal (eye) degeneration
- Neuro: improved cognition
- Fertility: restored fertility in aged mice by improving egg quality
Studies are being done now on humans. There are 10 published studies they reviewed from 2016 until now, looking at oral and IV NAD+. The studies were small, with the largest being 115 patients.
They found you need to build up your dose to make it tolerated better with less side effects. They do think it is safe and well tolerated. They found trending to lower blood pressure, decreased pro inflammatory gene expression, improvement in body composition and sleeping metabolic rate.
There were two studies which showed no change in the mitochondria.
My thoughts?
NAD+ has something real there. There is a lot of data showing mitochondrial function affects aging a lot. I love NAD improves the whole body on a cellular level. Brain, skin, heart, muscles all age. There is still a lot to be studied in humans, but the mice studies are very encouraging. As for the ideal amount and dosing etc, more information needs to be collected.
